#Open sesame origin free#
In addition, free tryptophan must compete with other amino acids for the “transportation system” to the brain. The tryptophan uptake mechanism is not yet fully understood however, it is believed that most of our tryptophan is bound to plasma albumin. BBB is formed by highly selective endothelial cells to prevent toxins or pathogens being circulated into the brain, while allowing the access of vital nutrients. Serotonin synthesis occurs in the periphery within the gut neurons and enterochromaffin cells and centrally within the neurons of the raphe in the brain stem. In order for the central serotonin production to occur, tryptophan first needs to cross blood-brain barrier (BBB) to reach the central nervous system. Tryptophan is the sole precursor of peripherally and centrally produced serotonin, a neurotransmitter which modulates a wide array of functions of our body including sleep, control of appetite, temperature, mood, and cognition.
It plays important roles in several metabolic functions. Tryptophan cannot be synthesised by our body and must be obtained through our diet. Tryptophan (/ˈtrɪptəfæn/) is one of the essential amino acids present in sesame seeds, which are limited in some vegetables such as soya 1. In addition, it is also a good source of dietary fibre and protein for our meals. Sesame seeds are rich in healthy unsaturated fats, consisting about 85% of total fatty acid content. From a nutrition perspective, sesame is indeed one of many treasures we inherited from our ancestors, who first started cultivating this crop thousands of years ago.
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